肝星状细胞在肝脏疾病中的作用

张磊; 李玉民

doi:10.3760/cma.j.issn.1673 9752.2014.01.021

肝星状细胞在肝脏疾病中的作用

张磊,
李玉民

730030 兰州大学第二临床医学院甘肃省消化系肿瘤重点实验室

基金项目: 国家自然科学基金(31270532)；甘肃省重点实验室建设计划项目(085RTSA002)

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出版历程

Effects of hepatic stellate cells in hepatic diseases

Zhang Lei,
Li Yumin

Second Clinical Medical College, Lanzhou University, Key Laboratory of Digestive System Tumors, Lanzhou 730030, China

摘要

摘要:
肝星状细胞(HSC)是肝脏内重要的非实质细胞之一，可分泌、释放多种胶原纤维和细胞骨架蛋白参与肝脏疾病的病理生理过程。正常状态下，HSC通过调节细胞外基质蛋白的合成和降解维持肝脏正常的组织结构；肝脏损伤时，HSC被激活，活化的HSC导致细胞外基质的增加是肝纤维化形成并最终导致肝硬化、肝衰竭的主要原因。因此，深入研究HSC在肝脏疾病发生与发展中的作用和机制，并研究与HSC相关的治疗策略，对于提高患者生存率具有一定意义。
- 肝肿瘤 /
- 肝纤维化 /
- 肝星状细胞
Abstract:
Hepatic satellite cell (HSC) is a kind of nonparenchymal cells in the liver, which releases various collagenous fibers and cytoskeletal proteins, playing an important role in the pathophysiological changes of the liver. In normal, HSCs maintain normal tissue architecture via regulating the synthesis and degradation of extracellular matrix (ECM) proteins. During liver injury, HSCs were activated. Activated HSCs are the main cells that lead to the accumulation of extracellular matrix, which is the main reason of hepatic fibrosis, cirrhosis and liver failure. Therefore, lucubrating the role and mechanism of HSC in the progress of hepatic disease and investiating the HSCrelated therapeutic strategies have practical significances for the prevention and treatment of liver injury and raise of patients′ survival rates in clinical practice.
- Liver neoplasms /
- Hepatic fibrosis /
- Hepatic satellite cells